ISSN 2305-3127 (Print)   
ISSN 2664-3790 (Online)

Original research


Recurrence of atrial fibrillation and late cardiovascular events in patients with persistent atrial fibrillation after restoration of sinus rhythm

U.P. Chernyaha-Royko 1, N.S. Pavlyk 2, M.S. Sorokivskyy 1, A.V. Aker 2, O.J. Zharinov 3

1 Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
2 Lviv Regional Cardiology Center, Ukraine, Lviv, Ukraine
3 Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

The aim – to study the role of late recurrences of AF in predicting adverse course of the disease in patients with persistent AF after cardioversion at 9-month follow-up.

Material and methods. The study included 120 patients with documented persistent AF who underwent successful cardioversion during hospitalization. After discharge patients were followed up for 9 months. Demographic and clinical-functional features, data of event monitoring (EV) for 7 days and Holter monitoring (HM ECG), treatment were compared in groups of patients with (n = 15) and without (n = 105) events.

Results. During 9-month follow-up, 15 (12.5 %) of 120 patients developed cardiovascular events: death (n = 1), stroke (n = 2), other thromboischemic events (n = 3), myocardial infarction (n = 1), decompensated heart failure (n = 4) and left ventricular ejection fraction (LVEF) reduction 10 % or more (n = 9). Patients with and without events had no significant differences in age, gender, weight, risk factors, HM ECG data and background pathology. Patients with events had a higher risk of CHA2DS2-VASc (p = 0.05), lower LV EF (p = 0.00009), more symptomatic recurrence of AF (p = 0.08), ventricular arrhythmias (p = 0.08) and short-run atrial tachyarrhythmia lasting up to 30 seconds (p = 0.05) according to EM; AF more often turned into permanent form (p = 0.002). Patients with events were more likely to receive digoxin (p = 0.04).

Conclusions. The main differences between patients with persistent AF after successful recovery of the sinus rhythm, in which events occurred within 9 months, were: higher score on the scale CHA2DS2-VASc, lower LV EF, more frequent presence of late recurrences of AF, including transition to a permanent form, more frequent short-term paroxysms of atrial tachyarrhythmias during EM after 9 months of observation, as well as the use of digoxin

Key words: persistent atrial fibrillation, relapses, cardiovascular complications.

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