Pathogenetic mechanism of stented coronary arteries restenosis and the role of vasculoendothelial growth factor A

M.P. Kopytsya, I.M. Kutya, I.R. Vyshnevska

References  

1. Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H, Inai Y, Silver M, Isner JM. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. Embo J.1999;18:3964-72.

2. Bagyura Z, Kiss L, Berta B, Szilágyi A, Hirschberg K, Széplaki G, Lux A, Szelid Z, Soós P, Merkely B. Association between VEGF Gene Polymorphisms and In-Stent Restenosis after Coronary Intervention Treated with Bare Metal Stent. Dis Markers.2017;7:9548-612. doi: 10.1155/2017/9548612.
3. Bräsen J. H, Kivelä A, Röser K, et al. Angiogenesis, vascular endothelial growth factor and platelet-derived growth factor-BB expression, iron deposition, and oxidation-specific epitopes in stented human coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21(11):1720–1726. doi: 10.1161/hq1101.098230.
4. Breunis W. B, Biezeveld M. H, Geissler J, Ottenkamp I, Kuipers M, Lam J, Hutchinson A, Welch R, Chanock S. J, Kuijpers T. W. Vascular endothelial growth factor gene haplotypes in Kawasaki disease. Arthritis and Rheumatism. 2006;54(5):1588–1594. doi: 10.1002/art.21811.
5. Celletti FL, Waugh JM, Amabile PG, Brendolan A, Hilfiker PR, Dake MD. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med. 2001;7:425-9.
6. Cheng G, Chang FJ, Wang Y, You PH, Chen HC, Han WQ, Wang JW, Zhong NE, Min ZQ. Factors Influencing Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Heart Disease: A Clinical Trial Based on 1-Year Follow-Up. Med Sci Monit. 2019;25:240–247. Published 2019 Jan 8. doi:10.12659/MSM.908692
7. Choi D.H, Kang S.N, Kimetal S.M. Growthfactors-loaded stents modified with hyaluronic acid and heparin for induction of rapid and tight re-endothelialization Colloids and Surfaces B. Biointerfaces. 2016;141:602–610.
8. Dangas G, Claessen B, Caixeta A, Sanidas E.A, Mintz G.S, Mehran R. In-stent restenosis in the drag-eluting stent era. J Am Coll Cardiol. 2010;56(23):1897-1907. doi: 10.1016/j.jacc.2010.07.028
9. Fattori R, Piva T. Drug-eluting stents in vascular intervention. Lancet 2003;361:247-249. PMID: 12547552 doi: 10.1016/S0140-6736(03)12275-1
10. Gossl M, Herrmann J, Tang H, Versari D, Galili O, Mannheim D, Rajkumar SV, Lerman LO, Lerman A. Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia. Basic Res Cardiol. 2009;104:695-706.
11. Grosskreutz CL, Anand-Apte B, Dupláa C, Quinn TP, Terman BI, Zetter B, D'Amore PA.Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro. Microvascular Research. 1999;58(2):128–136. doi: 10.1006/mvre.1999.2171
12. Hoeben A, Landuyt B, Martin S. Highley, Wildiers H, Allan T. Van Oosterom, Ernst A, De Bruijn. Vascular endothelial growth factor and angiogenesis. Pharmacol. Rev. 2004;56:549–580. doi: 10.1124/pr.56.4.3.
13. Hutter R, Carrick F.E, Valdiviezoetal C. Vascularendothe-lial growth factor regulates reendothelialization and neointima formationinamousemodelofarterialinjury. Circulation. 2004;110(16):2430–5. pmid:15477421
14. Kastrati A, Koch W, Berger PB, Mehilli J, Stephenson K, Neumann F, Beckerath N, Bo¨ttiger C, Duff G, Scho¨mig A. Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting. Journal of the American College of Cardiology. 2000;36(7):2168–2173. doi: 10.1016/S0735-1097(00)01014-7.
15. Katsaros KM, Kastl SP, Krychtiuk KA, Hutter R, Zorn G, Maurer G, Huber K, Wojta J, Christ G, Speidl WS..An increase of VEGF plasma levels is associated with restenosis of drug-eluting stents. EuroIntervention. 2014;10(2):224–30. pmid:24168783 doi: 10.4244/EIJV10I2A36
16. Kazmierczak E, Grajek S, Kowal J, Chmara E, Grygier M, Pyda M, Bogdanski P, Cieslewicz A, Jablecka A. Prognostic usefulness of IL-6 and VEGF for the occurrence of changes in coronary arteries of patients with stable angina and implanted stents. European Review for Medical and Pharmacological Sciences. 2014;18(15):2169-2175.
17. Keavney B. Outcome following percutaneous coronary intervention: not, so far, in our genes. Heart. 2003;89(3):247–248. doi: 10.1136/heart.89.3.247.
18. Khurana R, Zhuang Z, Bhardwaj S, Murakami M, De Muinck E, Yla-Herttuala S, Ferrara N, Martin JF, Zachary I, Simons M. Angiogenesis-dependent and independent phases of intimal hyperplasia. Circulation. 2004;110(16):2436–43. pmid:15477408
19. Koch W, Böttiger C, Mehilli J, Beckerath N, Neumann FJ, Schömig A, Kastrati A. Association of a CD18 gene polymorphism with a reduced risk of restenosis after coronary stenting. American Journal of Cardiology. 2001;88(10):1120–1124. doi: 10.1016/S0002-9149(01)02045-8.
20. Kollum M, Kaiser S, Kinscherf R, Metz J, Kübler W, Hehrlein C. Apoptosis after stent implantation compared with balloon angioplasty in rabbits. Role of macrophages. Arterioscler Thromb Vasc Biol. 1997;17(11):2383–8. pmid:9409205
21. Leopold JA. Neoatherosclerosis: another consequence of endothelial dysfunction?Circ Cardiovasc Interv. 2014;7(5):635-7. doi: 10.1161/circinterventions.114.001994.
22. Li D, Zhang C, Song F, Lubenec I, Tian Y, Song Q.H. VEGF regulates FGF-2 and TGF-1 expression in injury endothelial cells and mediates smooth muscle cells proliferation and migration, Microvascular Research.2009;77:(2):134–142.
23. Ohtani K, Egashira K, Hiasa K, Zhao Q, Kitamoto S, Ishibashi M, Usui M, Inoue S, Yonemitsu Y, Sueishi K, Sata M, Shibuya M, Sunagawa K. Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells. Circulation. 2004;110(16):2444–52. pmid:15477409
24. Osadnik T, Strzelczyk J. K, Reguła R, Bujak K, Fronczek M, Gonera M, Gawlita M, Wasilewski J, Lekston A, Kurek A, Gierlotka M, Trzeciak P, Hawranek M, Ostrowska Z, Wiczkowski A, Poloński L, Gąsior M. The relationships between polymorphisms in genes encoding the growth factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the restenosis process in patients with stable coronary artery disease treated with bare metal stent. Plos one. 2016;11(3) doi: 10.1371/journal.pone.0150500.e150500
25. Ramos C, Napoleao P, Selas M. Freixo C, Crespo MM, Carmo MM, Ferreira R, Pinheiro T. Prognostic value of vegf in patients submitted to percutaneous coronary intervention. Disease Markers.2014; (7). ID 135357.
26. Shiojima I, Walsh K. The role of vascular endothelial growth factor in restenosis: the controversy continues. Circulation. 2004;110:2283-6
27. Verschuren JJW, Trompet S, Postmus I, Lourdes Sampietro M, Heijmans BT, Houwing-Duistermaat J, Slagboom E, Jukema JW. Systematic testing of literature reported genetic variation associated with coronary restenosis: Results of The gender Study. PLOS ONE. 2012;7(8) doi: 10.1371/journal.pone.0042401.e42401
28. . Watson CJ, Webb NJ, Bottomley MJ, Brenchley PE. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: Correlation with variation in VEGF protein production. Cytokine 2000;12:1232–1235. doi: 10.1006/cyto.2000.0692
29. Weintraub WS. The pathophysiology and burden of restenosis. Am J Cardiol. 2007 Sep;100(5A):3K–9K. pmid:17719351
30. Wu X, Zhao Y, Tang C, Yin T, Du R, Tian J, Huang J, Gregersen H, Wang G. Re-endothelialization study on endovascular stents seeded by endothelial cells through up- or downregulation of VEGF. ACS Appl. Mater. Interfaces. 2016;8:7578–7589. doi: 10.1021/acsami.6b00152
31. Xuming Dai, Szymon Wiernek, James P Evans, Marschall S Runge. Genetics of coronary artery disease and myocardial infarction. World J Cardiol 2016;26;8(1):1–23. doi: 10.4330/wjc.v8.i1.1
32. Yang J, Zeng Y, Zhang C, Chen YX, Yang Z, Li Y, Leng X, Kong D, Wei XQ, Sun HF, Song CX. The prevention of restenosis in vivo with a VEGF gene and paclitaxel co-eluting stent. Biomaterials. 2013;34(6):1635-43. doi: 10.1016/j.biomaterials.2012.11.006.
33. Yin J, Shen L, Ji M, Wu Y, Cai S, Chen J, Yao Z, Ge1 J. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. Biomed Res Int. 2017;(6): Article ID 8730271. doi: 10.1155/2017/8730271.
34. Yu Y, Gao Y, Qin J, Kuang CY, Song MB, Yu SY, Cui B, Chen JF, Huang L. CCN1 promotes the differentiation of endothe -lial progenitor cells and reendothelialization in the early phase after vascular injury. Basic Res Cardiol. 2010;105:713–24.

[PDF] [Contents]