Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology

V.-P. Harjola, A. Mebazaa, J. Čelutkienė, D. Bettex, H. Bueno, O. Chioncel, M. Crespo-Leiro, V. Falk, G. Filippatos, S. Gibbs, A. Leite-Moreira, J. Lassus, J. Masip, C. Mueller, W. Mullens, R. Naeije, A.V. Nordegraaf, J. Parissis, J. Riley, A. Ristic, G. Rosano, A. Rudiger, F. Ruschitzka, P. Seferovic, B. Sztrymf, A. Vieillard-Baron, M. Yilmaz, S. Konstantinides

References

1. 1. Abe S, Yoshihisa A, Takiguchi M, et al. Liver dysfunction assessed by model for end-stage liver disease excluding INR (MELD-XI) scoring system predicts adverse prognosis in heart failure. PLoS One. 2014;9:e100618.
   2. Aiken LH, Sloane DM, Bruyneel L, et al. Nurse staffing and education and hospital mortality in nine European countries: a retrospective observational study. Lancet. 2014;383:1824-1830.
   3. Atiemo AD, Conte JV, Heldman AW. Resuscitation and recovery from acute right ventricular failure using a percutaneous right ventricular assist device. Catheter Cardiovasc Interv. 2006;68:78-82.
   4. Ayuela Azcarate JM, Clau TF, Ochagavia A, Vicho PR. Role of echocardiography in the hemodynamic monitorization of critical patients. Med Intensiva. 2012;36:220-232.
   5. Belohlavek J, Dytrych V, Linhart A. Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism. Exp Clin Cardiol. 2013;18:129-138.
   6. Berlin DA, Bakker J. Understanding venous return. Intensive Care Med. 2014;40:1564-1566.
   7. Bodson L, Bouferrache K, Vieillard-Baron A. Cardiac tamponade. Curr Opin Crit Care. 2011;17:416-424.
   8. Boissier F, Katsahian S, Razazi K, et al. Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome. Intensive Care Med. 2013;39:1725-1733.
   9. Bowers TR, O’Neill WW, Grines C, et al. Effect of reperfusion on biventricular function and survival after right ventricular infarction. New Engl J Med. 1998;338:933-940.
   10. Bowers TR, O’Neill WW, Pica M, Goldstein JA. Patterns of coronary compromise resulting in acute right ventricular ischemic dysfunction. Circulation. 2002;106:1104-1109.
   11. Breidthardt T, Vanpoucke G, Potocki M, et al. The novel marker LTBP2 predicts all-cause and pulmonary death in patients with acute dyspnoea. Clin Sci (Lond). 2012;123:557-566.
   12. Brodie BR, Stuckey TD, Hansen C, et al. Comparison of late survival in patients with cardiogenic shock due to right ventricular infarction versus left ventricular pump failure following primary percutaneous coronary intervention for ST-elevation acute myocardial infarction. Am J Cardiol. 2007;99:431-435.
   13. Bueno H, Lopez-Palop R, Bermejo J, et al. In-hospital outcome of elderly patients with acute inferior myocardial infarction and right ventricular involvement. Circulation. 1997;96:436-441.
   14. Bueno H, Lopez-Palop R, Perez-David E, et al. Delcan JL. Combined effect of age and right ventricular involvement on acute inferior myocardial infarction prognosis. Circulation. 1998;98:1714-1720.
   15. Candilio L, Malik A, Ariti C, et al. A retrospective analysis of myocardial preservation techniques during coronary artery bypass graft surgery: are we protecting the heart? J Cardiothorac Surg. 2014;9:1484.
   16. Chan P, Ogilby JD, Segal B. Tricuspid valve endocarditis. Am Heart J. 1989;117:1140-1146.
   17. Chandraratna PA, Mohar DS, Sidarous PF. Role of echocardiography in the treatment of cardiac tamponade. Echocardiography. 2014;31:899-910.
   18. Chen JM, Levin HR, Rose EA, et al. Experience with right ventricular assist devices for perioperative right-sided circulatory failure. Ann Thorac Surg. 1996;61:305-310.
   19. Cheung AW, White CW, Davis MK, Freed DH. Short-term mechanical circulatory support for recovery from acute right ventricular failure: clinical outcomes. J Heart Lung Transplant. 2014;33:794-799.
   20. Chioncel O, Vinereanu D, Datcu M, et al. The Romanian Acute Heart Failure Syndromes (RO-AHFS) registry. Am Heart J. 2011;162:142-153.
   21. Dalabih M, Rischard F, Mosier J. What’s new: the management of acute right ventricular decompensation of chronic pulmonary hypertension. Intensive Care Med. 2014;40:1930-1933.
   22. Damman K, Navis G, Smilde TD, et al. Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction. Eur J Heart Fail. 2007;9:872-878.
   23. Damman K, van Deursen VM, Navis G, et al. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol. 2009;53:582-588.
   24. Dell’Italia LJ, Lembo NJ, Starling MR, et al. Hemodynamically important right ventricular infarction: follow-up evaluation of right ventricular systolic function at rest and during exercise with radionuclide ventriculography and respiratory gas exchange. Circulation. 1987;75:996-1003.
   25. Deuse T, Schirmer J, Kubik M, Reichenspurner H. Isolated permanent right ventricular assistance using the HVAD continuous-flow pump. Ann Thorac Surg. 2013;95:1434-1436.
   26. Galie N, Humbert M, Vachiery J.L et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2016;37:67-119.
   27. Gayat E, Mebazaa A. Pulmonary hypertension in critical care. Curr Opin Crit Care. 2011;17:439-448.
   28. George I, Xydas S. Topkara VK, et al. Clinical indication for use and outcomes after inhaled nitric oxide therapy. Ann Thorac Surg. 2006;82:2161-2169.
   29. Ghignone M, Girling L, Prewitt RM. Volume expansion versus norepinephrine in treatment of a low cardiac output complicating an acute increase in right ventricular afterload in dogs. Anesthesiology. 1984;60:132-135.
   30. Ghio S, Klersy C, Magrini G, et al. Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension. Int J Cardiol. 2010;140:272-278.
   31. Giannitsis E, Potratz J,Wiegand U, et al. Impact of early accelerated dose tissue plasminogen activator on in-hospital patency of the infarcted vessel in patients with acute right ventricular infarction. Heart. 1997;77:512-516.
   32. Goldstein JA, Barzilai B, Rosamond TL, et al. Determinants of hemodynamic compromise with severe right ventricular infarction. Circulation. 1990;82:359-368.
   33. Goldstein JA, Harada A, Yagi Y, et al. Hemodynamic importance of systolic ventricular interaction, augmented right atrial contractility and atrioventricular synchrony in acute right ventricular dysfunction. J Am Coll Cardiol. 1990;16:181-189.
   34. Grant AD, Smedira NG, Starling RC, Marwick TH. Independent and incremental role of quantitative right ventricular evaluation for the prediction of right ventricular failure after left ventricular assist device implantation. J Am Coll Cardiol. 2012;60:521-528.
   35. Green EM, Givertz MM. Management of acute right ventricular failure in the intensive care unit. Curr Heart Fail Rep. 2012;9:228-235.
   36. Griffith KE, Jenkins E, Stulak J, et al. Long-term use of the CentriMag(R) Ventricular Assist System as a right ventricular assist device: a case report. Perfusion. 2012;27:65-70.
   37. Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC) endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36:3075-3128.
   38. Haddad F, Couture P, Tousignant C, Denault AY. The right ventricle in cardiac surgery, a perioperative perspective: I. Anatomy, physiology, and assessment. Anesth Analg. 2009;108:407-421.
   39. Haddad F, Couture P, Tousignant C, Denault AY. The right ventricle in cardiac surgery, a perioperative perspective: II. Pathophysiology, clinical importance, and management. Anesth Analg. 2009;108:422-433.
   40. Haddad F, Hunt S, Rosenthal DN, Murphy DJ. Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation. 2008;117:1436-1448.
   41. Haddad F, Peterson T, Fuh E, et al. Characteristics and outcome after hospitalization for acute right heart failure in patients with pulmonary arterial hypertension. Circ Heart Fail. 2011;4:692-699.
   42. Haddad F, Doyle R, Murphy DJ, Hunt SA. Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation. 2008;117:1717-1731.
   43. Heydari AA, Safari H, Sarvghad MR. Isolated tricuspid valve endocarditis. Int J Infect Dis. 2009;13:e109-e111.
   44. Hoeper MM, Granton J. Intensive care unit management of patients with severe pulmonary hypertension and right heart failure. Am J Respir Crit Care Med. 2011;184:1114-1124.
   45. Hoeper MM, Granton J. Intensive care unit management of patients with severe pulmonary hypertension and right heart failure. Am J Respir Crit Care Med. 2011;184:1114-1124.
   46. Jacobs AK, Leopold JA, Bates E, et al. Cardiogenic shock caused by right ventricular infarction: a report from the SHOCK registry. J Am Coll Cardiol. 2003;41:1273-1279.
   47. Januzzi JL Jr, Filippatos G, Nieminen M, Gheorghiade M. Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section. Eur Heart J. 2012;33:2265-2271.
   48. Jardin F, Vieillard-Baron A. Is there a safe plateau pressure in ARDS? The right heart only knows. Intensive Care Med. 2007;33:444-447.
   49. Jurcut R, Giusca S, La GA, et al. The echocardiographic assessment of the right ventricle: what to do in 2010? Eur J Echocardiogr. 2010;11:81-96.
   50. Kapur NK, Paruchuri V, Jagannathan A, et al. Mechanical circulatory support for right ventricular failure. JACC Heart Fail. 2013;1:127-134.
   51. Kelly DM, Kutney-Lee A, McHugh MD, et al. Impact of critical care nursing on 30-day mortality of mechanically ventilated older adults. Crit Care Med. 2014;42:1089-1095.
   52. Kiernan MS, French AL, DeNofrio D, et al. Preoperative three-dimensional echocardiography to assess risk of right ventricular failure after left ventricular assist device surgery. J Card Fail. 2015;21:189-197.
   53. Kinch JW, Ryan TJ. Right ventricular infarction. N Engl J Med. 1994;330:1211-1217.
   54. Kinn JW, Ajluni SC, Samyn JG, et al. Rapid hemodynamic improvement after reperfusion during right ventricular infarction. J Am Coll Cardiol. 1995;26:1230-1234.
   55. Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2014;35:3033-3069.
   56. Krabatsch T, Potapov E, Stepanenko A, et al. Biventricular circulatory support with two miniaturized implantable assist devices. Circulation. 2011;124:S179-S186.
   57. Kucher N, Boekstegers P, Muller O.J, et al. Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism. Circulation. 2014;129:479-486.
   58. Kurzyna M, Zylkowska J, Fijalkowska A, et al. Characteristics and prognosis of patients with decompensated right ventricular failure during the course of pulmonary hypertension. Kardiol Pol. 2008;66:1033-1039.
   59. Lancellotti P, Price S, Edvardsen T, et al. The use of echocardiography in acute cardiovascular care: recommendations of the European Association of Cardiovascular Imaging and the Acute Cardiovascular Care Association. Eur. Heart J Acute Cardiovasc Care. 2015;16:119-146.
   60. Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28:1-39.
   61. Lankeit M, Friesen D, Aschoff J, et al. Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism. Eur Heart J. 2010;31:1836-1844.
   62. Lankeit M, Jimenez D, Kostrubiec M, et al. Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation. 2011;124:2716-2724.
   63. Lankeit M, Kempf T, Dellas C, et al. Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism. Am J Respir Crit Care Med. 2008;177:1018-1025.
   64. Laster SB, Ohnishi Y, Saffitz JE, Goldstein JA. Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia. Circulation. 1994;90:1398-1409.
   65. Laster SB, Shelton TJ, Barzilai B, Goldstein JA. Determinants of the recovery of right ventricular performance following experimental chronic right coronary artery occlusion. Circulation. 1993;88:696-708.
   66. Lau GT, Tan HC, Kritharides L. Type of liver dysfunction in heart failure and its relation to the severity of tricuspid regurgitation. Am J Cardiol. 2002;90:1405-1409.
   67. Lewis JF, Webber JD, Sutton LL, et al. Discordance in degree of right and left ventricular dilation in patients with dilated cardiomyopathy: recognition and clinical implications. J Am Coll Cardiol. 1993;21:649-654.
   68. Lheritier G, Legras A, Caille A, et al. Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with early acute respiratory distress syndrome: a multicenter study. Intensive Care Med. 2013;39:1734-1742.
   69. Liang M, Chin J, Pasupati S. Complete heart block in late presentation of inferior STEMI successfully treated with percutaneous coronary intervention. J Invasive Cardiol. 2011;23:E219-E221.
   70. Logeart D, Isnard R, Resche-Rigon M, et al. Current aspects of the spectrum of acute heart failure syndromes in a real-life setting: the OFICA study. Eur J Heart Fail. 2013;15:465-476.
   71. Maggioni AP, Dahlstrom U, Filippatos G, et al. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010;12:1076-1084.
   72. Maisel A, Mueller C, Adams K Jr, et al. State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail. 2008;10:824-839.
   73. Markel TA, Wairiuko GM, Lahm T, et al. The right heart and its distinct mechanisms of development, function, and failure. J Surg Res. 2008;146:304-313.
   74. Marzec LN, Ambardekar AV. Preoperative evaluation and perioperative management of right ventricular failure after left ventricular assist device implantation. Semin Cardiothorac Vasc Anesth. 2013;17:249-261.
   75. Mayo PH, Beaulieu Y, Doelken P, et al. American College of Chest Physicians/La Societe de Reanimation de Langue Francaise statement on competence in critical care ultrasonography. Chest. 2009;135:1050-1060.
   76. McLaughlin VV, Shillington A, Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation. 2002;106:1477-1482.
   77. McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012;14:803-869.
   78. Mebazaa A, Yilmaz MB. Levy P, et al. Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine. Eur J Heart Fail. 2015;17:544-558.
   79. Megalla S, Holtzman D, Aronow WS, et al. Predictors of cardiac hepatopathy in patients with right heart failure. Med Sci Monit. 2011;17:CR537-CR541.
   80. Mehta SR, Eikelboom JW, Natarajan MK, et al. Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction. J Am Coll Cardiol. 2001;37:37-43.
   81. Meyer G, Vicaut E, Danays T, et al. Fibrinolysis for patients with intermediate-risk pulmonary embolism. New Engl J Med. 2014;370:1402-1411.
   82. Moran AE, Forouzanfar MH, Roth GA, et al. The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study. Circulation. 2014;129:1493-1501.
   83. Morelli A, Teboul JL, Maggiore SM, et al. Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study. Crit Care Med. 2006;34:2287-2293.
   84. Moreyra AE, Horvitz L, Presant SB, Kostis JB. Resolution of complete heart block after right coronary artery angioplasty. Am Heart J. 1988;115: 179-181.
   85. Mullens W, Abrahams Z, Francis GS, et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol. 2009;53:589-596.
   86. Naeije R, Brimioulle S, Dewachter L. Biomechanics of the right ventricle in health and disease (2013 Grover Conference series). Pulm Circ. 2014;4:395-406.
   87. Naito A, Tanabe N, Jujo T, et al. Pentraxin3 in chronic thromboembolic pulmonary hypertension: a new biomarker for screening from remitted pulmonary thromboembolism. PLoS One. 2014;9:e113086.
   88. Nath J, Foster E, Heidenreich PA. Impact of tricuspid regurgitation on long-term Survival. J Am Coll Cardiol. 2004;43:405-409.
   89. Nieminen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27:2725-2736.
   90. Park SJ, Park JH, Lee HS, et al. Impaired RV global longitudinal strain is associated with poor long-term clinical outcomes in patients with acute inferior STEMI. JACC Cardiovasc. Imaging. 2015;8:161-169.
   91. Pegg TJ, Selvanayagam JB, Karamitsos TD, et al. Effects of off-pump versus on-pump coronary artery bypass grafting on early and late right ventricular function. Circulation. 2008;117:2202-2210.
   92. Price LC, Wort SJ. Finney SJ, et al. Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. Crit Care. 2010;14:R169.
   93. Puls M, Dellas C, Lankeit M, et al. Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism. Eur. Heart J. 2007;28:224-229.
   94. Rajaram SS, Desai NK, Kalra A, et al. Pulmonary artery catheters for adult patients in intensive Care. Cochrane Database Syst Rev. 2013;2:CD003408.
   95. Rajdev A, Garan H, Biviano A. Arrhythmias in pulmonary arterial hypertension. Prog Cardiovasc Dis. 2012;55:180-186.
   96. Ramamurthy S, Anandaraja S, Matthew N. Percutaneous coronary intervention for persistent complete heart block complicating inferior myocardial infarction. J. Invasive Cardiol. 2007;19:E372-E374.
   97. Ristic AD, Imazio M, Adler Y, et al. Triage strategy for urgent management of cardiac tamponade: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2014;35:2279-2284.
   98. Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23:685-713.
   99. Sandoval J, Torbicki A. Atrial Septostomy. The Right Ventricle in Health and Disease / Eds. N. Voelkel, D. Schranz. N.Y.: Humana Press, Springer. 2015:419-437.
   100. Schurner A, Wilhelm MJ, Falk V, et al. Recurrent clotting of a continuous-flow right ventricular assist device: repeated thrombolysis with two different protocols. J Cardiothorac Vasc Anesth. 2015;29:1614-1617.
   101. Slaughter MS, Pagani FD, Rogers JG, et al. Clinical management of continuous-flow left ventricular assist in advanced heart failure. J Heart Lung Transplant. 2010;29:S1-S39.
   102. Song HK, von HC, Jespersen CM, et al. Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations. Ann Thorac Surg. 2014;97:1630-1635.
   103. Spinar J, Parenica J, Vitovec J, et al. Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) Main registry. Crit Care. 2011;15:R291.
   104. Sztrymf B, Prat D, Jacobs FM, et al. Renal replacement therapy in patients with severe precapillary pulmonary hypertension with acute right heart failure. Respiration. 2013;85:464-470.
   105. Sztrymf B, Souza R, Bertoletti L, et al. Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension. Eur Respir J. 2010;35:1286-1293.
   106. Topol EJ, Goldschlager N, Ports TA, et al. Hemodynamic benefit of atrial pacing in right ventricular myocardial infarction. Ann Intern Med. 1982;96:594-597.
   107. Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 2012;42:S1-44.
   108. Van Deursen VM, Damman K, Hillege HL, et al. Abnormal liver function in relation to hemodynamic profile in heart failure Patients. J Card Fail. 2010;16:84-90.
   109. Ventetuolo CE, Klinger JR. Management of acute right ventricular failure in the intensive care unit. Ann Am Thorac Soc. 2014;11:811-822.
   110. Verbrugge FH, Dupont M, Steels P, et al. Abdominal contributions to cardiorenal dysfunction in congestive heart failure. J Am Coll Cardiol. 2013;62:485-495.
   111. Vieillard-Baron A, Price L.C, Matthay M.A. Acute cor pulmonale in ARDS. Intensive Care Med. 2013;39:1836-1838.
   112. Vieillard-Baron A, Prin S, Chergui K, et al. Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit. Am J Respir Crit Care Med. 2002;166:1310-1319.
   113. Vieillard-Baron A, Schmitt JM, Augarde R, et al. Acute cor pulmonale in acute respiratory distress syndrome submitted to protective ventilation: incidence, clinical implications, and prognosis. Crit Care Med. 2001;29:1551-1555.
   114. Vlahakes GJ. Right ventricular failure following cardiac surgery. Coron Artery Dis. 2005;16:27-30.
   115. Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ. Mechanisms of right heart failure - a work in progress and a plea for failure prevention. Pulm Circ. 2013;3:137-143.
   116. Voelkel NF, Quaife RA, Leinwand LA, et al. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecularmechanisms of right heart failure. Circulation. 2006;114:1883-1891.
   117. Vonk-Noordegraaf A, Haddad F, Chin KM, et al. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. J Am Coll Cardiol. 2013;62:D22-D33.
   118. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013;9:73-81.
   119. Werdan K, Gielen S, Ebelt H, Hochman JS. Mechanical circulatory support in cardiogenic shock. Eur Heart J. 2014;35:156-167.
   120. Wesley RC, Jr, Lerman BB, DiMarco JP, et al. Mechanism of atropine-resistant atrioventricular block during inferior myocardial infarction: possible role of adenosine. J Am Coll Cardiol. 1986;8:1232-1234.
   121. West E, Barron D.N, Harrison D, et al. Nurse staffing, medical staffing and mortality in intensive care: an observational study. Int J Nurs Stud. 2014;51:781-794.
   122. Zehender M, Kasper W, Kauder E, et al. Eligibility for and benefit of thrombolytic therapy in inferior myocardial infarction: focus on the prognostic importance of right ventricular infarction. J Am Coll Cardiol. 1994;24:362-369.
   123. Zehender M, Kasper W, Kauder E, et al. Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. New Engl J Med. 1993;328:981-988.